Protein Phosphatases and Calcium/Calmodulin-Dependent Protein Kinase II-Dependent Synaptic Plasticity
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چکیده
منابع مشابه
Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity.
Synaptic plasticity in hippocampal CA1 pyramidal cells requires a delicate balance of protein kinase and protein phosphatase activities. Long-term potentiation (LTP) after intense synaptic stimulation often results from postsynaptic Ca 2 influx via NMDAtype glutamate receptors and activation of multiple protein kinases. In contrast, weaker synaptic stimulation paradigms can induce long-term dep...
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Extracellular application of protein kinase inhibitors was used to examine the role of calcium/calmodulin-dependent protein kinase II (CaM-KII) in synaptic transmission in the CA1 region of rat hippocampus. Bath application of the broad spectrum, membrane permeable kinase inhibitor H7 (250 microM) decreased excitatory synaptic responses elicited in hippocampal slices. Whereas H7 inhibits severa...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2004
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3602-04.2004